Comparison · Growth-hormone secretagogues
Ipamorelin vs MK-677
Both stimulate growth-hormone release via the ghrelin receptor, but the similarity ends there.
Reading this research reference
The information below concerns the research subject, not proof of the identity or performance of a supplied material. Check the original sources and your laboratory’s requirements; product documentation must be assessed separately for the exact batch.
At a glance
| Attribute | Ipamorelin | MK-677 |
|---|---|---|
| Class | Pentapeptide | Oral small molecule |
| Target | GHSR-1a | GHSR-1a |
| Half-life | ~2 hours | ~24 hours |
| Route | Lyophilised peptide | Oral |
| Cortisol / prolactin | Minimal | Some appetite / water retention |
Mechanism
Both compounds bind the ghrelin receptor (GHSR-1a) on somatotrophs in the anterior pituitary, triggering a pulsatile growth-hormone release. Ipamorelin is selective and short-acting; MK-677 produces a sustained, day-long elevation of GH and IGF-1 in published studies.
Half-life
MK-677 has a reported half-life of around 24 hours.
Research applications
Ipamorelin is favoured in research where investigators want a clean, ghrelin-receptor-selective probe without confounding cortisol or prolactin movement. MK-677 is favoured where chronic, steady IGF-1 elevation is the variable under study.
Side-effect signal in literature
Ipamorelin shows minimal cortisol/prolactin effects in published research. MK-677 has documented appetite stimulation (via ghrelin pathway), mild water retention and possible insulin sensitivity shifts in longer-term studies.
Frequently asked questions
Are Ipamorelin and MK-677 the same class?+
Both are growth-hormone secretagogues acting on the ghrelin receptor (GHSR-1a), but Ipamorelin is a peptide and MK-677 is an oral small molecule with very different pharmacokinetics.
Does either raise cortisol or prolactin?+
Ipamorelin is notable for minimal effects on cortisol and prolactin in published research; MK-677 has shown some appetite and water-retention effects via ghrelin signalling.
Ipamorelin on Bio Mech
Product details, batch documentation and support for the compound discussed above. Research use only.
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