SS-31 Elamipretide | Cardiolipin Research Peptide | Bio Mech

SS-31 (D-Arg-Dmt-Lys-Phe-NH2) is a synthetic tetrapeptide engineered to accumulate selectively at the inner mitochondrial membrane, where it binds cardiolipin and stabilises supercomplex assembly. Published preclinical work has explored SS-31 in cardiac ischaemia–reperfusion models, age-related mitochondrial dysfunction panels, and renal and skeletal-muscle bioenergetic studies.

Because the peptide carries a Dmt (dimethyl-tyrosine) residue and a D-arginine, SS-31 is significantly more synthetically demanding than standard L-amino-acid peptides — which is why batch testing and supplier selection matter even more than usual.

No laboratory reports have yet been verified for publication against Bio Mech stock. Ask support about documentation for the exact production lot before ordering.

Janoshik Analytical is the default verification partner for SS-31, with secondary verification on selected batches through additional European laboratories. Per-batch reports are published on the lab reports page and tied to the batch number printed on every vial cap.

Lyophilised SS-31 is supplied as a sterile white powder under inert atmosphere. Hold unopened vials at 2–8 °C; transfer to −20 °C if reconstitution will not happen within 8–12 months. Reconstitute with bacteriostatic water for a two-month (60-day) in-use stability window under refrigeration; protect from prolonged light exposure to preserve the Dmt residue.

Most laboratories work at 1–5 mg/ml stock concentrations. SS-31 is sensitive to repeat freeze–thaw cycles — aliquot the full reconstituted volume before any freeze to preserve potency across multi-week protocols.

Bio Mech dispatches SS-31 from our Germany, USA or China hub with 5–18 day tracked delivery and 5–18 day Spain-wide tracked coverage.

No laboratory reports have yet been verified for publication against Bio Mech stock. Ask support about documentation for the exact production lot before ordering.

UK research clients receive SS-31 via tracked dispatch from our Germany, USA or China hub, typically arriving in 5–18 days. and VAT and customs handling are quoted transparently at checkout — no surprise charges on delivery.

No laboratory reports have yet been verified for publication against Bio Mech stock. Ask support about documentation for the exact production lot before ordering.

No laboratory reports have yet been verified for publication against Bio Mech stock. Ask support about documentation for the exact production lot before ordering.

US buyers should confirm institutional research-purchasing policy before ordering. SS-31 is supplied strictly for research use and is not approved for human consumption.

SS-31 and MOTS-c are often studied side-by-side in mitochondrial-bioenergetics panels, but they operate via completely distinct mechanisms. SS-31 binds cardiolipin at the inner mitochondrial membrane, stabilising electron-transport-chain supercomplex assembly. MOTS-c is encoded inside mitochondrial DNA and acts through AMPK-linked metabolic signalling.

Stocking both compounds from the same supplier keeps documentation and packaging consistent across a comparative bioenergetics panel.

SS-31 contains a Dmt residue and a D-arginine, both of which are easy to substitute with cheaper L-tyrosine and L-arginine analogues by a careless or dishonest supplier. Mass-spec identity confirmation on every batch is non-negotiable — HPLC alone cannot detect that kind of substitution.

No laboratory reports have yet been verified for publication against Bio Mech stock. Ask support about documentation for the exact production lot before ordering.